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The amylin and GLP-1 pathways both converge on a satiety effect, but via different neural circuits

Similar to the BPC 157 effect on sphincters function, BPC 157 exhibited a particular anti-reflux effect in healthy (i.e., increase of pressure within lower esophageal sphincter, decrease of pressure within pyloric sphincter), while also rescuing sphincters failure (i.e., decreased pressure) in esophagitis rats (increase toward the normal values) (31, 32)

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The consensus among conservative, evidence-driven physicians is that BPC-157 should only be used, if at all, in controlled research settings until its safety is definitively proven